Acrylamide (AA) has a toxic effect on both animals and humans. The present study investigated the potential protective effect of silymarin (SIL), as an antioxidant against AA toxicity in cardiac tissue. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay The rats were divided into four groups as follows: control, AA, SIL, and AA+SIL groups. The results obtained showed that AA reduces the values ​​of Hb content, PCV and red blood cell counts. Furthermore, AA enhanced the enzymatic activities of LDH and CK, altered lipid profile, digested DNA, induced oxidative stress, and developed histopathological changes in the heart of treated rats. On the other hand, concomitant administration of AA and SIL attenuated the variation of the above parameters, suggesting a potential protective effect of SIL against AA-induced cardiac toxicity. Practical applications It is necessary to decrease the level of acrylamide in various foods. Regular consumption of SIL could offer protection to the heart and improve hematological changes and DNA damage induced by AA.IntroductionAcrylamide (AA) is a small vinyl compound. It has the chemical structure of (CH2=CO–NH2). It is used to produce polyacrylamides, used in wastewater treatment, dye synthesis, gel chromatography, textile processing, electrophoresis, pharmaceutical industry, photography, tapes and gels. AA is also found in tobacco smoke and is produced primarily in foods that are fried, roasted, grilled, or baked at temperatures above 120°C. In the Maillard reaction, the NH2 of asparagine and the carbonyl group of glucose react together to produce acrylamide. Previous studies in the literature have shown that AA is absorbed very quickly and effectively through the gastrointestinal system. The cellular toxicity of AA begins with its biotransformation by cytochrome P4502El into a more potent reactive molecule, glycidamide, which has greater reactivity towards proteins, hemoglobin and DNA than AA itself. AA is easily transported throughout the body due to its very small size and hydrophilicity. Experimentally, the administration of AA can have toxic and carcinogenic effects on both animals and humans. It was demonstrated that AA could alter hematological parameters and lipid profile in treated rats. Heart disease is among the most important causes of death in the world. In the heart, AA caused structural changes indicating tissue degeneration. Furthermore, it caused an increase in serum lactate dehydrogenase (LDH) (EC: 1.1.1.27) and creatine kinase (CK) (EC: 2.7.3.2.). AA can cause oxidative stress such as lipid peroxidation effect (LPO) and reduction of antioxidant enzyme activities. Antioxidant administration is known to ameliorate drug-induced toxicity. Please note: this is just an example. Get a custom paper from our expert writers now. Get a Custom Essay Silymarin (SIL) is produced from the leaves, seeds and fruits of Silibum marianum (milk thistle) which belongs to the Asteraceae family. SIL contains flavolignans, such as taxifolin, silycristin, silydianin, silybin A, silybin B, isosilybin A, and isosilybin B. SIL has multiple therapeutic effects including antioxidant, hepatoprotective, anti-inflammatory, antibacterial, antiallergic, antimutagenic, antiviral, antineoplastic, and antithrombotic agents and has vasodilatory actions. It has been suggested that.