Asthma is a widespread and highly treatable lung condition characterized by inflammation of the lungs, increased reactivity of the airways, and reversibility or obstruction of airflow. Many people around the world, children and even adults, are diagnosed with asthma. Asthma symptoms are associated with breathing and the respiratory system. Asthma symptoms vary in frequency and intensity and include coughing, wheezing, increased mucus production, difficulty breathing, and shortness of breath. During an asthma attack, the bronchial muscles tighten, the lining of the respiratory tract swells, and mucus production in the respiratory tract is excessive, resulting in narrowing of the airways. The main factors of origin of asthma are genetic predisposition to type I hypersensitivity (atopy), acute and chronic inflammation of the airways and bronchial hyperresponsiveness to a variety of stimuli. Inflammation contains many cell types and various inflammatory mediators, but T helper type 2 (TH2) cell activity may be instrumental in the pathogenesis of asthma. The typical atopic form of asthma is related to an exorbitant TH2 reaction against environmental antigens. TH2 cells produce cytokines that are reported for most properties of asthma: IL-4 (interleukin 4)-stimulated IgE (immunoglobulin E) production, IL-5 (interleukin 5)-activated eosinophils, and IL- 13 (interleukin 13) stimulates mucus production and also promotes the production of IgE by B cells. IgE coats submucosal mast cells and releases granule contents upon exposure to the allergen. This involves two waves of reaction: an early or immediate phase and a late phase. The early reaction is dominated by bronchoconstriction, mucus production increases to...... middle of paper...... infusion in the asthmatic state. These medications are commonly used when needed to control symptoms. The primary effect of -adrenoreceptor agonists in asthma is to dilate the bronchi through a direct action on -adrenoreceptors of smooth muscle. They relax the bronchial muscles whenever spasmogens are involved. They also limit the release of mediators from mast cells and the release of TNF- from monocytes and increase mucus clearance by cilia operation. Every use of medications will have side or adverse effects. Common side effects of -adrenoceptor agonists are tremor, tachycardia, and cardiac dysrhythmia. In conclusion, asthma is one of the respiratory diseases related to lung conditions with a chronic inflammatory airway disorder that causes repetitive wheezing, dyspnea, chest tightness, and cough. And it can be treated with anti-asthma medications, including albuterol.
tags