[1]Schizophrenia is a chronic and serious brain disorder, although most people may call it a disease. With this disorder the person is more likely to experience "imaginary friends",[2] to hear voices that do not exist and to be very paranoid. People who suffer from schizophrenia are often introverted and easily agitated. [3]The main reason for these symptoms is known to be paranoia, although the symptoms may vary depending on the person and the type of schizophrenia they may have. [6] [7] There are five types of schizophrenia, which include paranoid, disorganized, catatonic, undifferentiated, and residual schizophrenia. [3] The disturbance is believed to be environmental. Trauma, emotional disturbances and stress are mentioned as people who have had difficulty with schizophrenia would have no trace of the genetically based disorder in their family.[5] Most people don't discover they have schizophrenia until late childhood. It is rare for children to discover this before the age of ten. While others may not find out until they are in their late thirties or forties. Symptoms can develop over time. Females appear to experience symptoms later than males.[3]Schizophrenia affects approximately 1% of the population. Schizophrenia affects men approximately 1.5 times more often than women. Schizophrenia is more likely in relatives of a schizophrenic person. People with an aunt, uncle, cousin or grandparent with the disorder are more likely to contract it than any bystander. Someone with a parent or sibling with the disorder has a 10% chance of developing schizophrenia. The most likely to have this disorder is an identical twin. Identical twins, twins (brother or sister) have a 40-65% chance of giving... middle of paper... begins to relax supercoils and alter DNA and interacts with the DNA helicase SGS1 and plays a role in DNA recombination, also in cellular aging and in maintaining genome stability. Alternative splicing produces multiple transcript variants. Additional variants of the gene have been described, but their full length is not known. Schizophrenia is basically gene-based, although environmental factors exist. Environmental factors are not fully proven in all people with schizophrenia. The main factors are genes that are unspecified due to the unusual mutation, which cannot yet be fully known by scientists. Now the TOP3B genetic mutation is known as a gene associated with schizophrenia, but scientists will continue to try to investigate more genes like this for more unique mutations seen in many people with schizophrenia.