Guillian-Barré syndrome (GBS) results from a disorder associated with Campylobacter jejuni infection. Campylobacter is known to have multiple pathological forms of GBS, including demyelinating and axonal forms. GBS can cause weakness in the limbs and lack of reflexes. There is proximal and distal weakness and respiratory cases are often involved. GBS can lead to paralysis, depending on the virulence. If sufficiently virulent, GBS will affect the respiratory system, which often lands patients on ventilation machines due to difficulty breathing. There are six subtypes of GBS, of which acute inflammatory demyelinating polyneuropathy is the most common form. The immune system attacks Schwan cell membranes in response to a bacterial or viral infection. This will lead to weakness of reflexes and small sensory changes. Weak motor reflexes follow sensory symptoms. This can lead to respiratory failure if the breathing muscles are affected. As the immune system attacks the Schwann cells, which are the cells responsible for producing myelin for the nerves, the myelin sheath will be damaged. Most patients' symptoms can be resolved with remyelination. Miller-Fisher syndrome is a rare form of GBS. This subtype is distinguished by inverse paralysis rather than the order of the most common types of GBS. There is abnormal eye coordination that can lead to paralysis of the eye muscles. This weakness of the eye muscles essential for eye movement is called ophthalmoplegia. Ophthalmoplegia is a cardinal feature, meaning it is the main clinical symptom by which the diagnosis is made. Additionally, loss of full control of body movements or ataxia is present in Miller-Fisher syndrome. For Miller-Fisher syndrome, ataxia u...... middle of document ...... emedicine.medscape.com/article/315632-overview#aw2aab6b2b2>."Guillain-Barré syndrome (GBS). " Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, August 23, 2012. Web. March 19, 2014. “Gullian Barre Syndrome and Its Variants.” neuropathy.org. Np, nd Web. March 19, 2014. “Miller Fisher NINDS Syndrome Information Page.” Miller Fisher Syndrome Information Page: National Institute of Neurological Disorders and Stroke (NINDS). Np, nd Web. March 19, 2014. “Result Filters.” National Center for Biotechnology Information. US National Library of Medicine, nd Web. March 17. 2014. .
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